Please submit a letter of interest, a full CV, and contact information for three academic references. Informal inquiries may be made to: Maria G. Castro ([email protected]) or Pedro R. Lowenstein ([email protected]).
A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
A Research Laboratory Specialist position is available in the Department of Neurosurgery and the Department of Cell and Developmental Biology at the University of Michigan Medical School. The goal of our research program is to elucidate the molecular and cellular mechanisms involved in brain tumor formation, and the role of specific signaling pathways and stem cells in tumor progression and resistance to therapies. The project also involves cancer cell genome-editing technologies, epigenetics, whole cancer genome sequencing, bioinformatics analysis and DNA repair mechanisms. This project has a strong translational component to develop and implement novel therapeutic strategies in human clinical trials for brain cancer.
The Research Laboratory Associate will perform highly complex experimental procedures in one or more areas of work under the supervision of the Principal Investigators and/or higher-level research staff. Employee will be required to conduct in vivo and in vitro experiments, collect and process tumor samples, collect and analyze data, and assist in developing new and/or specialized research methodologies. The successful applicant will be responsible for the characterization, quality control, archiving and National and International distribution to collaborators, of genetically engineered cell systems, gene therapy vectors and plasmids. Plasmids will also need to be validated and after careful quality control, deposited in a national plasmid repository that will distribute them to Universities and other scientific organizations on our behalf. They will also be required to perform complex statistical calculations and data analysis, prepare PowerPoint presentations and figures for manuscripts, perform library research on specified topics and prepare bibliographies, assist with FDA submissions, IND and patent submission preparation. In addition, the successful candidate will contribute to preparation and updating of regulatory protocols and revisions (i.e. animal/IBC protocols, IACUC, EHS, etc).
They will assist in the supervision and training of junior lab members (e.g. undergraduate students, junior graduate and rotation students and/or junior technicians) in routine lab techniques and lab safety.
Our laboratories offer state-of-the-art facilities and a very productive and exciting research environment.
The individual will be a key member of the Lowenstein-Castro Research Team and will work closely with the PIs. There will be opportunities to participate in assembling manuscripts, participate in grant writing and attending national meetings to present the project data resulting from the work performed.
Minimum of Bachelor’s in Biochemistry, Neuroscience, Molecular Biology, Bioinformatics, or Computational Biology, or related fields.
Must have at least 2+ years of various laboratory and data analysis experience.
Must have experience with basic molecular and cellular biology techniques and tools including isolation of DNA, RNA, and protein from tissue and cultured samples, PCR, Western blot, immunostaining of
tissue sections and cell preparations, cell culture.
Demonstrated experience working with
Experience with cell culture, and in vitro cell-based assays (e.g. tissue dissection, tissue processing, sectioning, immunohistochemistry, western blot, ELISA and microscopy).
Must be proficient with standard computer software (e.g. MS word, excel, PowerPoint, Adobe Photoshop, Illustrator) and data analysis software and willing to learn new programs as needed.
Organization, attention to detail, punctuality, and flexibility required.
Ability to work independently with limited supervision as required.
Excellent interpersonal skills and ability to work with others in a collaborative environment.
Strong oral and written communication skills.
Background in molecular biology or biochemistry preferred.
Experience with cell culture and differentiation protocols and flow cytometry preferred.
Experience with image analysis techniques and programs preferred.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
U-M COVID-19 Vaccination Policy
COVID-19 vaccinations are now required for all University of Michigan students, faculty and staff across all three campuses, including Michigan Medicine. This includes those working or learning remotely. More information on this policy is available on the Campus Blueprint website or the U-M Dearborn and U-M Flint websites.
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.