This individual will serve as a bioinformatician and computational scientist for integrative multi-omics projects. The candidate will independently carry out bioinformatics/ computational analyses and interpretation of complex, cutting-edge, high-dimensional genomic data sets generated by next generation sequencing instruments in conjunction with transcriptomic, single-cell and liquid biopsy sequence data. These methods will be used to enhance risk prediction for precision medicine applications. Together with the principal investigator, the candidate will manage, analyze, and communicate data produced in collaborative projects focused on basic and translational research in cancer biology, and will help with publication efforts. Accepted candidates will benefit from the diverse expertise across the computational/statistical and laboratory-based research groups, which have existing collaborations. Ongoing studies include, but are not limited to, mechanisms of response and resistance to immunotherapy, identification of tissue and blood-derived genomic biomarkers of response to therapies, including immunotherapy and targeted therapies. This work involves utilization of already established computational pipelines as well as fine-tuning and development of novel computational approaches. The candidate will work as a team with junior analysts and will be involved in their supervision. This individual will communicate analytical results and details of the computational analyses effectively to the principal investigator and to collaborating investigators.
Develop and apply computational and statistical methods for the integrated analysis of high throughput sequencing studies that include whole genome, whole exome, methylation, RNA sequencing, single cell and/or liquid biopsy platforms.
Maintain and troubleshoot computational pipelines.
Develop analysis methodology leveraging high dimensional multi-omics sequence data, including defining in detail data requirements, data sources and proper data collection procedures.
Develop and implement data collection quality assurance procedures to ensure validity and reliability of study results.
Supervise junior data analyst and oversee troubleshooting of computational pipelines.
Perform data analysis and interpretation; utilize knowledge of statistics and quantitative analysis. Present research data.
Contribute to writing sections of manuscripts/publications.
May present data at meetings.
Supervision of Others:
The candidate will be involved with supervision of junior data analysts and computational scientists in the group.
Equipment, Machine, or Tool Requirements:
Experience with computers and servers and knowledge of Linux/UNIX as well as other common operating systems such as Mac OS and Windows is necessary.
Experience with server configuration and troubleshooting preferred.
Ability to use the internet and web-based scholarly search engines.
Master's degree in biostatistics, statistics, mathematics, epidemiology, or related quantitative field required.
Three (3) years of related experience required.
Demonstrated ability on significant graduate project or additional doctoral education may substitute for experience, to the extent permitted by the JHU equivalency formula.
JHU Equivalency Formula: Demonstrated ability on significant graduate project or additional doctoral education may substitute for experience.For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.
Doctoral level degree preferred.
Special Knowledge, Skills, and Abilities:
Experience with Linux/UNIX.
Experience with code development, optimization, and testing.
Experience in a sequencing center.
Knowledge and practical experience with programming languages (e.g., Java, C or C++), a scripting language (e.g., Perl, Python), and a statistical environment (e.g. R).
Must be detail-oriented, focused, creative, and independent.
Proficiency in both written and spoken English with excellent communication skills.
Familiarity with common computational biology tools and software packages, such as Bioconductor.
Knowledge of system administration and networking.
Classified title: Sr. Biostatistician
Working title: Sr. Bioinformatician
Role/Level/Range: ACRP 37.5/E/04/ME
Starting Salary Range: $60,945.12- $83,862.72 (commensurate with experience)
Employee group: Fulltime
Employee Status: Exempt
Schedule: Monday-Friday –9:00am-5:30pm 37.5hrs/Wk - Telecommuting due to covid
Location: CRB II - 1550 Orleans St., Baltimore, MD
Department name: 10002938-SOM Onc Upper Aerodigestive Cancer
Personnel area (School): SOM – School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the HR Business Services Office at email@example.com. For TTY users, call via Maryland Relay or dial 711.
The following additional provisions may apply depending on which campus you will work. Your recruiter will advise accordingly.
During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
Equal Opportunity Employer Note: Job Postings are updated daily and remain online until filled.
Johns Hopkins University remains committed to its founding principle, that education for all students should be grounded in exploration and discovery. Hopkins students are challenged not just to learn but also to advance learning itself. Critical thinking, problem solving, creativity, and entrepreneurship are all encouraged and nourished in this unique educational environment. After more than 130 years, Johns Hopkins remains a world leader in both teaching and research. Faculty members and their research colleagues at the university's Applied Physics Laboratory have each year since 1979 won Johns Hopkins more federal research and development funding than any other university. The university has nine academic divisions and campuses throughout the Baltimore-Washington area. The Krieger School of Arts and Sciences, the Whiting School of Engineering, the School of Education and the Carey Business School are based at the Homewood campus in northern Baltimore. The schools of Medicine, Public Health, and Nursing share a campus in east Baltimore with The Johns Hopkins Hospital. The Peabody Institute, a leading professional school of music, is located on Mount Vernon Place in downtown Bal...timore. The Paul H. Nitze School of Advanced International Studies is located in Washington's Dupont Circle area.