The candidate will perform cell and molecular biology work relating to development of small molecule therapies for high containment viruses and development of tissue models for studying infection and disease treatment. The work will involve evaluating the action and activity of small molecules for inhibiting virus infection. High throughput screening techniques will be applied at high containment and followed up with mechanistic analysis of activity using biochemical and cell biology techniques. Therapies will be evaluated in animal models but will also involve development of tissue models as substitutes for preclinical treatment evaluation. The work will be performed in part in the NEIDL BSL4 laboratory.
Must have graduated from a PhD graduate program from an accredited school. Specific skills required are cell cultivation and RNA and DNA transfection methods. Must have published manuscripts in peer reviewed journals. Experience with blood and tissue derived primary cell types, including macrophages is highly desirable. Previous experience working with viruses is also desirable. Previous experience with statistical analysis of disease model data and quantitative analysis of microscopy images is desirable. Must be able to train and work at BSL4 with Ebola virus or similar viruses as well as SARS-CoV-2. Assist in experimental design and communicate results. Must be able to pass a FBI background check and be approved for work with select agents.
The National Emerging Infectious Diseases Laboratories (NEIDL) is part of a national network of secure facilities that study infectious diseases - whether they occur naturally or are introduced deliberately through bioterrorism. The NEIDL is dedicated to the development of diagnostics, vaccines and therapeutics to combat emerging and re-emerging infectious diseases. In addition to Bio Safety Level (BSL)-2 and BSL-3 laboratories, the NEIDL houses BSL-4 laboratories that will operate at the highest level of containment. The NEIDL will add to the growing life sciences industry in the region, throughout the Commonwealth of Massachusetts, and across the country.
Individuals seeking affiliation with or employment within the NEIDL may be subject to the following suitability requirements. Failure to meet any of these requirements may result in ineligibility for employment or affiliation:
Criminal Background Check: To be completed in accordance with BU Public Safety guidelines and all federal, state and local laws and regulations.
Basic Background Check: Includes, but is not limited to, verification of:
Social Security Number;
Licenses and credentials;
Sexual Offender Registry Information (SORI) check;
Credit history check;
RMV/DMV driving record, if required.
Medical Clearance Process: includes Research Occupational Health Program (ROHP) evaluation, drug screening, initial psychological screening, and immunization/titer level review completed in accordance with NEIDL Medical Surveillance Policy for all employees working at the NEIDL.
Training and Education: to be completed in accordance with Section 8, Ongoing Personnel Reliability Program, for all employees working at the NEIDL.
Individuals seeking or required to have approval to work with Select Agents will be subject to the following additional requirements:
Department of Justice Criminal Background Check and Fingerprinting: To be completed in accordance with CDC requirements as part of application to have access to Select Agents.
Select Agent Use Approval: to be completed in accordance with all regulations including the requirements of the Boston Public Health Commission (BPHC), Institutional Biosafety Committee (IBC) and the Center for Disease Control (CDC).
Please note, any individual working in the NEIDL facility and granted unescorted access, is subject to
periodic background reviews, including but not limited to: criminal background, credit history, drug screening, and behavioral evaluations;
periodic checks and regular renewals of security credentials, any applicable licenses, and verification of the successful completion of any required training at the facility
Search of person, clothing and effects prior to entry into or egress from NEIDL
When applicable, individuals will be required to maintain all applicable clearances and licenses and to disclose any changes in circumstances that could compromise access to the facility.
Continued employment/ affiliation is contingent upon strict adherence, at all times, to all applicable safety and security rules, procedures, and protocols, as well as required training regimens.
DO NOT SUBMIT APPLICATIONS THROUGH THE BU WEBSITE
Please send all application materials to: Dr. Robert Davey at email@example.com
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by law. We are a VEVRAA Federal Contractor.
Internal Number: 2414
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