Proficient senior research laboratory specialist with a sophisticated understanding of techniques and a solid foundation in the underlying science to work in the Radiopharmeceutical Therapy and Dosimetry (RTD) Lab in the Radiological Physics Division, Department of Radiology. Works independently and manages daily research projects. Make intellectual contributions to scientific research interests of the lab. In collaboration with principal investigator, make research project decisions that may alter research objectives and direction. Co-authors peer-reviewed manuscripts and may contribute to writing grants. Applies independent thought to making decisions with the principal investigator. Develop, design, and manage substantial research projects that support the overall mission of the lab, coordinates own objectives towards this end. Perform sophisticated data analysis utilizing extensive knowledge base and varied methods experience. \
In clinical lab, performs and develops clinical validation protocols. Will present at departmental/divisional meetings, and provides training to other individuals who may be assigned to the laboratory on a regular or temporary basis. Act as consultant to refine or adapt methodologies to fit research objectives. Collaborates in development of new technologies, protocols and uses of equipment. The senior research specialist will assist the principal investigator and the other faculty in the lab in the development and coordination of specific research projects, experimentation, data collection and analysis, and organization of the laboratory.
Duties and Responsibilities:
Seeking an individual with experience in cell culture and standard molecular biology techniques as well as the ability to perform pre-clinical animal studies and maintain a transgenic mouse colony.
Performs clinical and/or research lab tests and experiments.
Follows, establishes and/or devises procedures and protocols and is expected to improve them as needed.
Will utilize appropriate technique to design and perform laboratory tests and/or experiments.
Participates in planning experiments and evaluating/interpreting test results utilizing detailed knowledge of research laboratory procedures and practices.
Selects, develops, performs and evaluates research methods
Operates appropriate equipment
Reports and records outcomes/results of all tests.
Exchanges routine information in an appropriate manner requiring good oral and written communication
Regular interaction with students, vendors, post-doctoral fellows, faculty members, and other clinical fellows, that may include training.
Monitors biohazard/radiation safety standards and proper handling of potentially hazardous chemical and biological agents and/or radiation sources in the workplace
May be responsible for routine operational activities such as; ordering supplies and materials, reviewing inventory, maintaining up to date records of tests, etc.
Preventative maintenance of equipment.
Monitors inventory levels and proper storage of materials and supplies in accordance with establishes policies and procedures.
A Bachelor’s degree in biochemistry, molecular biology or related field required.
Master’s degree preferred. Master's degree can be used in place of some required experience, to the extent permitted by the JHU Equivalency.
At least 4 years of experience required, in tissue culture techniques, including transfection, ability to generate and maintain a stable cell line from tumor tissue explants, MTT cell kill assay, mycoplasma testing; familiarity with colony formation assay a plus.
Special Knowledge, Skills, and Abilities:
Ability to maintain a transgenic mouse or rat colony, perform genotyping
Ability to conduct pre-clinical drug and radiopharmaceutical studies, including, intraductal, IP, tail vein injections and oral gavage.
Knowledge and practice of the following:
Sub-cutaneous, left cardiac ventricle and mammary fat pad tumor cell inoculation
Immune-blotting, Southern and Northern blotting
RNA and DNA extraction, protein kinase assay, luciferase assay
Spheroid growth and soft agar assays, including migration and invasion
DNA cloning, point deletion, insertion mutagenesis and real-time quantitative PCR
Proficiency in Microsoft Excel and Word; willing and able to maintain lab web site
JHU Equivalency Formula: 18 graduate degree credits may substitute for one year of experience.
Classified Title: Sr. Research Specialist Working Title: Sr. Research Specialist Role/Level/Range: ACRP/04/MC Starting Salary Range: $45,195-$62,225 Employee group: Full Time Schedule: Monday-Friday/8:30am-5:00pm/40 hours Exempt Status: Exempt Location: 04-MD:School of Medicine Campus Department name: 10003375-SOM Rad Medical Physics Imaging Personnel area: School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
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The following additional provisions may apply depending on which campus you will work. Your recruiter will advise accordingly.
During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.
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Johns Hopkins University remains committed to its founding principle, that education for all students should be grounded in exploration and discovery. Hopkins students are challenged not just to learn but also to advance learning itself. Critical thinking, problem solving, creativity, and entrepreneurship are all encouraged and nourished in this unique educational environment. After more than 130 years, Johns Hopkins remains a world leader in both teaching and research. Faculty members and their research colleagues at the university's Applied Physics Laboratory have each year since 1979 won Johns Hopkins more federal research and development funding than any other university. The university has nine academic divisions and campuses throughout the Baltimore-Washington area. The Krieger School of Arts and Sciences, the Whiting School of Engineering, the School of Education and the Carey Business School are based at the Homewood campus in northern Baltimore. The schools of Medicine, Public Health, and Nursing share a campus in east Baltimore with The Johns Hopkins Hospital. The Peabody Institute, a leading professional school of music, is located on Mount Vernon Place in downtown Bal...timore. The Paul H. Nitze School of Advanced International Studies is located in Washington's Dupont Circle area.