The Sr. Research Specialist is responsible for managing large transgenic fly and mosquito colonies, as well as performing laboratory management responsibilities. The candidate will also assist post-doctoral fellows and graduate students in the design and implementation of experiments related to insect and chemosensory neuroscience. As part of the lab, he/she will collaborate with the Principal Investigator (PI) to design and develop protocols, and oversee study-related activities on several projects. With limited supervision by the PI, he/she will design and perform laboratory experiments on independent research projects. He/she will: 1) be responsible for preparing progress reports and writing scientific papers resulting from the research projects, 2) provide day-to-day supervision and train junior postdoctoral fellows and students on the techniques and skills needed in the lab, 3) collaborate with the PI in overseeing the administrative and scientific implementation of the research protocols for our research studies. With appropriate direction by the PI, he/she will function as a leader in maintaining and circulating research protocols among the program members, ensuring Standard Operating Procedures (SOPs) are being met by lab members, setting agendas and schedules for routine research-related meetings and other activities, and implementing laboratory protocols for research projects of our insect chemosensory research program. With guidance from the PI or the PI's designee, he/she will also function in capacities required for laboratory function, including ordering laboratory reagents and conducting experiments. He/she will assist the principal investigator in organization of the laboratory and the completion of experiments, and will routinely communicate with lab members regarding scientific and other issues.
Specific Duties & Responsibilities
Manage and maintain fly stocks; this includes making fly food vials weekly and transferring fly lab stocks. Independently perform these duties and/or manage students to perform these tasks.
Manage and maintain mosquito stocks; this includes PCR genotyping and blood-feeding of mosquitoes on mice, the candidate must be comfortable with mouse handling. Independently perform these duties and/or manage students to perform these tasks.
Plan and conduct experiments after consultation with investigator. Work may include making protocol modifications within the parameters set by investigator.
Process analyzed data into figures for scientific publications. Utilize specialized knowledge to interpret results, e.g. reading controls, evaluating results.
Use scientific knowledge and lab experience to evaluate whether component parts of experiments are working as they should and optimize the related protocols as necessary. Will help troubleshoot experimental problems for members of the research group as requested by the investigator.
Assist post-doctoral fellows and graduate students in the design and implementation of experiments related to insect and chemosensory neuroscience. May participate in protocol development, efficiency, and productivity. Assists in development of new techniques and instruments.
Train new lab members, junior postdoctoral fellows and students on established laboratory experimental techniques and laboratory safety policies.
Apply published research methods to current experimental work by investigating published protocols and discussing them with PI.
Monitor inventory levels, order materials and supplies including lab consumables, glassware, and reagents in accordance with established policies and procedures.
Maintain accurate, detailed data records, inventories and procedures in laboratory notebooks and electronically on file servers, ensuring their appropriate file backup, description, accuracy, and completion.
Coordinate lab efforts in generating new mutant and transgenic strains of mosquitoes after discussion with investigator.
Supervise undergraduates or other volunteers in fly and mosquito husbandry.
Manage and perform general laboratory tasks, including maintaining laboratory equipment and service contracts, preparing common reagents.
Ensure laboratory conforms to all institutional safety and compliance guidelines and policies relevant to the work conducted in the laboratory both on an ongoing day-to-day basis and for annual inspections.
Manage shipping/receiving of reagents and research organisms, in compliance with all institutional and federal guidelines in support of collaborations with both internal and external investigators. This requires specialized knowledge of, and previous experience with, protocols for shipping of insects for research purposes.
Follow established procedures or protocols and utilize aseptic technique to perform laboratory experiments which include: PCR, molecular biology and cloning, genetic crosses with flies, genetic crosses with mosquitoes, and microscopy experiments.
With guidance by the principal investigator (PI), develop and define research projects and strategies on the insect chemosensory research program.
Independently design and perform laboratory experiments for specific insect chemosensory research projects in the lab
Present data at meetings held within the laboratory group and institution.
Suggest ideas for new research projects.
Work with the PI to prepare and submit chemical safety and animal protocols.
Coordinate, organize and arrange regular scientific meetings for team members as needed; prepare agendas, material for, and coordination of meetings with researchers.
Maintain detailed working knowledge of protocols.
Design and implement spreadsheets and databases for tracking and management of research data and related research materials.
Perform statistical analyses on research data using standard statistical software.
Perform literature searches for presentations and publications.
Ensure accuracy and timeliness of data collection.
Interacts regularly with members of the research team regarding data management and the status and progress of ongoing studies.
Meets regularly with the PI to discuss study progress.
Participates in all mandatory meetings of the research program and helps to prepare material for these meetings.
Prepares reports as required by the principal investigators and senior scientists on the program.
Is highly experienced and knowledgeable and complies with all standard laboratory research protocols, regulations, and policies; may instruct introductory level research personnel in these guidelines and policies.
Help to purchase new laboratory computers and interact with our IT department to ensure that computers and printers are functioning.
Manage distribution and sharing of resources in support of collaborative research efforts both within the institution and with those external to the institution, meeting all appropriate policy expectations and guidelines.
Help to order or oversee ordering reagents. This will require monitoring inventory levels of materials and supplies, as well as communication with and knowledge of relevant vendors. In addition, he or she will process invoices for services received. Proper handling and organization of paperwork is required to ensure that laboratory spending is constrained to budgetary limits.
Responsible for the composition of protocols for laboratory processes.
Assist in the completion and submission of grants.
Monitor equipment performance and maintenance, and be responsible for scheduling repairs and renewing service contracts when necessary. Responsible for maintenance of equipment shared across several laboratories. Duties include managing and developing an appropriate invoicing and billing process related to use of equipment, if applicable. Train new users, and assist with usage when needed. Responsible for scheduling preventative maintenance and keeping the systems in working order, as well as addressing and troubleshooting any problems.
Assist the principal investigator and other investigators in our group with laboratory organization and completion of experiments.
Communicate laboratory issues with personnel in a timely manner.
Direct and schedule maintenance, repair and certification of laboratory equipment.
Renew and amend animal care and use protocols.
Renew biosafety registrations.
Keep the laboratory prepared for safety inspections.
Assist in the completion of ACUC, IRB and FDA applications.
Bachelor's degree in biology, chemistry or related field.
Four (4) years' experience in a comparable laboratory performing relevant techniques.
Master's degree, with related graduate research, may substitute for experience to the extent permitted by the * JHU Equivalency Formula: 30 undergraduate degree credits (semester hours) or 18 graduate degree credits may substitute for one year of experience. Additional related experience may substitute for the required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job. *
At least 4 years of specialized experience in a comparable laboratory performing relevant techniques, coupled with knowledge of biological sciences, molecular biology, or chemistry.
Experience working with mosquitoes and/or Drosophila is recommended.
Previous experience with the HopkinsOne system and ordering from the JHU CORE store, JHU Supply Store, and external vendors is a plus.
Familiar with PC and Apple computers and standard computer software, including the Microsoft Office package, Adobe Acrobat, Adobe Illustrator, and Adobe Photoshop.
Special Knowledge, Skills, and Abilities
Experience handling and managing Drosophila and mosquito insect colonies
Able to perform scientific research through conducing laboratory experiments using a variety of techniques, such as microscopy, DNA extraction, PCR, DNA cloning, DNA ligations, animal genotyping, microdissection of insect tissue, phenotypic analyses, and genetic crosses.
Knowledge of basic research principles required, particularly with respect to insect chemosensory research.
Proficiency in the use of software applications, databases, spreadsheets, and word processing required.
Skills and expertise in handling transgenic mosquito lines and performing olfactory behavioral assays.
Skilled at the lab bench
Excellent organizational, attention to detail, and time management skills required.
Able to manage multiple and competing priorities.
Have excellent communication skills.
Work well in a team environment.
Classified Title: Sr. Research Specialist Working Title: Sr. Research Specialist Role/Level/Range: ACRP/04/MC Starting Salary Range: $44,749 - $61,610 /Commensurate with Experience Employee group: Full Time Schedule: Monday - Friday, 8:30 AM - 5:00 PM / 37.5 Hours per week Exempt Status: Exempt Location: 04-MD:School of Medicine Campus Department name: 10002905-SOM Neuro Sci Neuroscience Personnel area: School of Medicine
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