The responsibilities of the individual in this position will be to independently pursue new projects as well as work collaboratively with the other 7 members of the lab (principal investigator, 3 post-docs, and 3 research technicians) on ongoing projects. In addition, the individual will interact with undergraduate students who work part time. In addition to performing laboratory experiments, ongoing responsibilities will include the management of a transgenic mouse colony, the performance of animal treatment, behavioral testing, and surgeries, and the ordering of laboratory supplies.
Specific duties & responsibilities: Demonstrate organization for lab related projects, scientific curiosity related to the neuromuscular disease field, teamwork and leadership towards problem solving in both common and project specific issues, and flexibility
Exhibit a sophisticated understanding of the neuromuscular disease field as it pertains to spinal muscular atrophy
Manage a human autopsy tissue bank consisting of paraformaldehyde, glutaraldehyde, and flash frozen tissues from control and spinal muscular atrophy patients used for the characterization and development of therapeutics of human spinal muscular atrophy through several molecular, biochemical, and immunological experiments as well as collaborations with other institutions.
Oversee and participate in collaborations with outside institutions involving human autopsy tissue analysis.
Assist medical professionals in autopsy tissue collection to increase tissue bank content for both control and SMA tissues
Develop, coordinate, and actively participate in a study to characterize human SMA pathology using human autopsy tissue by applying various techniques such as but not limited to cryostat or vibrato me sectioning, immunohistochemistry, light, fluorescent, and confocal microscopy, and RT-PCR to investigate SMA human pathology following BSL-2 biohazard standards followed by data collection and analysis with minimal PI supervision
Independently process and deliver presentations of scientific data for colleagues as well as conferences via poster and seminars with approval of PI
Manage and make purchases of basic laboratory supplies and specific project necessities such as live animal ordering as well as receive, stock, and maintain necessary lab inventory
Perform necessary administrative tasks such as but not limited to grant progress reports and Fed-ex account upkeep
Educate, train, and supervise undergraduate students that assist in characterization of human SMA pathology
Dissect and harvest tissues such as spinal cord from perfused animals when required
Assist in conducting behavioral studies such as righting time, hind limb strength, and grid navigation and collecting data for analysis when needed
Assist in the maintenance and recording of control and Δ7 SMA mouse colony inventory when needed
Perform or assist in intracerebroventricular (ICV) injections of ASO's to analyze potential therapeutic effects when needed
Meet weekly with PI and colleagues to review lab data, troubleshoot problems, prioritize tasks, and discuss newly published scientific literature relevant to the neuromuscular disease field
Minimum qualifications (mandatory):
B.S. Degree in Sciences/ Biology, and a minimum of two years related experience.
Master's in Sciences/Biology
Special knowledge, skills, and abilities:
Animal Behavior Testing
Classified Title: Research Specialist II Working Title: Research Specialist II Role/Level/Range: ACRP/03/MB Starting Salary Range: $38,920-$53,520(commensurate with experience) Employee group: Full Time Schedule: M-F 8:30 am - 5:00 pm Exempt Status: Exempt Location: 04-MD:School of Medicine Campus Department name: 10003524-SOM Neuro Neuromuscular Personnel area: School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
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