Berkeley Lab's Joint Genome Institute (JGI) Division has an opening for a Senior Research Associate. Will perform production and research assignments, data analysis and interpretation related to various technology in next-generation sequencing (NGS) library construction and tasks necessary to meet the goals of the large-scale genome, transcriptome and epigenome characterization effort. Tasks involve evaluation of sample quality, library construction, library quality evaluation and submission using LIMS systems. Will be responsible for understanding the latest sequencing technology, support or lead new technology development and integrate new protocols onto JGI sequencing platforms. Will also interpret rolling quality control (rQC) reports, troubleshoot process failures and participate in the optimization of protocols. Emphasis will be placed on meeting the library production goals as well as conducting research and development (R&D) experiments.
What You Will Do:
Perform work assignments to create various types of libraries from samples (DNA, RNA, chromatin or cell/nuclei) from JGI users' including prokaryote, eukaryote organisms, and environmental samples.
Understand and interpret QC results and implement modifications as needed.
Follow up with accurate data entry into LIMS system.
Interpret rQC reports to evaluate library quality and identify failure and propose solutions.
Independently design and perform experiments, summarize results, and provide conclusions on R&D projects.
Understand general library development issues relating to production needs, identify areas of improvement and offer feedback.
Troubleshoot & optimize current library construction protocols to meet scientific research goals.
Serve as a technical resource to other members in the group and recommend process and database improvements.
Assist in project coordination with Project Management.
Maintain an accurate and detailed laboratory notebook: document any deviations from established protocols.
Write, update and maintain Standard Operating Procedures.
Attend and present project progress in group meetings.
Additional Responsibilities as needed:
Present project updates at genome technology group meetings.
Participate in cross-team and cross-group training to develop knowledge of the entire workflow.
Maintain a clean and safe working environment.
Contribute to data, text in group publications.
Assist group members in performing new molecular biology experiments and protocols.
Research articles and literature to explore new techniques or applications.
What is Required:
Bachelor's degree preferred and two to five years of experience lab experience in biology, microbiology, genetics or related fields with increasing responsibility, or an MS degree.
Demonstrated experience with laboratory and molecular biology techniques such as nucleic acid purification, DNA cloning, PCR, NGS library preparation and sequencing.
Good understanding of how scientific principles apply to the problem being studied.
Experience troubleshooting problems, conducting an analysis of data and recording experimental data.
Good analytical, record-keeping and organizational skills necessary for working in a laboratory environment.
Effective communication skills to work in a research team environment with a diverse group of scientific and technical personnel.
Must demonstrate efficient time management skills and ability to multitasking in a fast-paced environment.
Proficient computer skills.
Demonstrated ability to serve as a technical resource, troubleshoot laboratory process problems and recommend process improvements.
Additional Desired Qualifications:
Experience in sequence data analysis/ interpretation.
Knowledge in gene expression, epigenetic regulations, and plant genomics.
Knowledge of Environmental, Health and Safety, Security, Procurement and business management policies and procedures.
Experience with lab automation and data management.
Experience mentoring research technicians and students.
The posting shall remain open until the position is filled.
This is a full time, career appointment.
Full-time, M-F, non-exempt (hourly paid) from overtime pay.
This position is represented by a union for collective bargaining purposes.
Salary will be determined based on range by collective bargaining agreement.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at DOE Joint Genome Institute (JGI) — 2800 Mitchell Dr., Walnut Creek, CA.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law."
Internal Number: 86725
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.