Classified Title: Sr. Research Specialist Working Title: Role/Level/Range: ACRP/04/MC Starting Salary Range: $44,749-$58,000.00 Employee group: Full-Time Schedule: M-F; 8:30am-5:00pm Exempt Status: Exempt Location: 04-MD:School of Medicine Campus Department name: 10002817-SOM DOM Pulmonary Personnel area: School of Medicine
The Sr. Research Specialist will join the research program in the Laboratory for Nontuberculous Mycobacteria (NTM) and Bronchiectasis at the Johns Hopkins Department of Medicine to perform basic and translational laboratory research on NTM and bronchiectasis. As part of the study team, will collaborate with the Principal Investigator (PI) to design and develop protocols, and oversee study-related activities on several projects. With limited supervision by the PI, will design and perform laboratory experiments on his or her independent research projects. Responsible for developing and organizing data reports and writing scientific papers resulting from the research projects. Provide day-day supervision and train junior postdoctoral fellows and students on the techniques and skills needed in the lab. Collaborate with the PI in overseeing the administrative and scientific implementation of the research protocols for NTM and bronchiectasis research studies. With appropriate direction by the PI, functions as a leader in maintaining and circulating research protocols among the program members, setting agendas and schedules for routine research-related meetings and other activities, processing laboratory protocols for basic and translational research projects of the NTM and bronchiectasis research program.
Specific duties & responsibilities:
Participate in laboratory research in a comprehensive NTM and bronchiectasis research program, and develop and design research protocols to investigate molecular mechanisms of drug resistance in NTM, investigate blood-based biomarkers of NTM and bronchiectasis, and pursue clinical translation of the laboratory findings.
With limited guidance by the principal investigator (PI), develop and define research projects and strategies on the NTM and bronchiectasis research program.
Independently design and perform laboratory experiments for specific NTM and bronchiectasis research projects in the lab
Use special skills and expertise to prepare and apply cell lines, human bio specimens, and animal models to NTM and bronchiectasis research
Use a variety of laboratory tools, such as cell manipulations, cell inoculation to produce animal pulmonary hypertension models, molecular genetic tools, Western blotting, PCR, genetic analysis to conduct laboratory NTM and bronchiectasis research
Organize, analyze and summarize the research data to prepare laboratory and scientific meeting reports on NTM and bronchiectasis research.
Present data at meetings.
Write/draft scientific manuscripts for publications from the research projects
Participate as a member of collaborative group study team in study design and development of NTM and bronchiectasis research projects.
Help train and supervise junior postdoctoral fellows and students with the above skills and expertise for NTM and bronchiectasis research
Suggest ideas for new research projects.
Conduct training sessions for junior personnel and students on the program.
Works with the PI to prepare and submit annual IRB renewal requests, amendments and adverse event reports according to IRB requirements for human NTM and bronchiectasis tissue collection related to the clinical translational NTM and bronchiectasis research.
Maintains excellent working knowledge of all assigned study protocols and reporting requirements.
Coordinates, organize and arrange regular scientific meetings for the team members as needed; prepares agendas, material for, and coordination of meetings with researchers on the thyroid research program in the lab.
Train research staff on job functions and performs quality assurance reviews for the scientific data.
Maintains detailed working knowledge of protocols
Designs spreadsheets and databases for tracking and management of research data
Perform statistical analyses on research data, particularly NTM and bronchiectasis genetic-clinical correlation data using standard statistical software
Performs literature searches for presentations, and publications
Ensures accuracy and timeliness of data collection.
Interacts regularly with members of the research team regarding data management and the status and progress of ongoing studies.
Data entry and management using database and other computer software
Track and assess quality of data entry and abstraction.
Meets regularly with the PI and other senior members of the team to discuss study progress. Participates in all mandatory meetings of the research program and helps to prepare material for these meetings.
Prepares reports as required by the principal investigators and senior scientists on the program. Is highly experienced and knowledgeable and complies with all standard laboratory research protocols, regulations, and policies; may instruct introductory level research personnel in these guidelines and policies.
Minimum qualifications (mandatory):
Requires a minimum of a bachelor's degree in biology, chemistry, or other related science
A minimum of four years of related experience and expertise in laboratory management.
Requires a minimum of a master's degree in biology (e.g. Molecular Biology, Molecular Bioengineering or Genetics)
A minimum of two years of experience and expertise directly and specifically in wet laboratory work.
Special knowledge, skills, and abilities: Able to perform scientific research through conducing laboratory experiments using a variety of techniques, such as cell culture, mycobacterial culture, microscopy, DNA extraction, PCR, Western blotting, tumor animal procedures, and others. Skills and expertise in handling special macrophage cell lines and developing NTM and bronchiectasis animal models. Proficiency in the use of software applications, databases, spreadsheets, and word processing required. Excellent organizational, attention to detail, and time management skills required. Knowledge of genetic-clinical translational research and principles required, particularly in mycobacterial research. Actual strong research experience is required. Able to manage multiple and competing priorities. Have excellent communication skills.
Any specific physical requirements for the job: Sitting in a normal seated position for extended periods of time Reaching by extending hand(s) or arm(s) in any direction Finger dexterity to manipulate objects with fingers rather than with whole hand or arm, for example, using a keyboard. Communication skills using the spoken word. Ability to see within normal parameters Ability to hear within normal ranges Ability to move about
Supervisory responsibility (indicate the number and type of persons supervised by incumbent): Supervises the junior personnel (typically 4-5 fresh or junior trainees—e.g., students and junior postdoctoral fellows) to provide them technical assistance and operational advice on microbiologic research. Trains these personnel involved in performing experimental performance, data collection and data entry as well as provides resource support to other personnel for unplanned problems. Help interview, hire and discipline the personnel in the mycobacteria and bronchiectasis research program.
The successful candidate(s) for this position will be subject to a pre-employment background check.
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During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.
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